Impact yezvinodhaka-coated contact lens pane hutano hweocular surface

Mumakore gumi apfuura, kutsvagisa uye kusimukira mumishonga yemaziso kwakatungamira kune nzira dzinonakidza dzekuburitsa, senge nguva-yekuburitsa maimplants uye mucus-inopinda nanoparticles, iyo inogona kuvandudza kushanda kwezvinodhaka, kuderedza mhedzisiro, uye kuderedza kushushikana pamusoro pekuteerera kwevarwere neophthalmic regimens. .madonhwe.modes.
Malenzi ekubatika anoonekwa seanovimbisa magadzirirwo, uye madhiri-akavharwa lenzi ari kuongororwa hutachiona, yakaoma eye syndrome (DES), glaucoma, uye allergies.Poshi
Первая контактная линза с лекарственным покрытием, получившая одобрение FDA ранее в этом году (Acuvue Theravision с кетотифеном [Johnson & Johnson Vision]), представляет собой этафилкон А для ежедневного применения, обладающий противовоспалительными свойствами, обычно используемый в глазных каплях от аллергии. Yekutanga drug-coated contact lens kugamuchira FDA mvumo kutanga kwegore rino (Acuvue Theravision with Ketotifen [Johnson & Johnson Vision]), is a daily etafilcon A anti-inflammatory, inowanzoshandiswa mumadonhwe eziso allergy.ketotifen.

Anonyanya Kuzivikanwa Malenzi
Macontact lens anoshanda semadonhwe emeso.2 Sezvo iyi iri nzira nyowani yekuisa, panguva yekiriniki yekudzidza kweiyi yekuonana lens, vandaishanda navo neni takaunganidza imwe data kuti ikwane.
Takaongorora 2 miedzo yekiriniki ine yakafanana multicentre randomized controlled design, iyo yaisanganisira vanopfuura 500 varwere.Mhedzisiro, ichangobva kuburitswa muKliniki uye Yekuyedza Optometry, penda mufananidzo unovimbisa wevarwere, varapi, uye ramangwana remaitiro aya.3
Kushandiswa kwenguva refu kwemadonhwe eziso kunozivikanwa kuti kunotungamirira kune zvinodhaka-induced conjunctivitis - tsvuku, kuputika uye kupisa kwemaziso mushure mekugara kwenguva refu kune zvigadzirwa zvemadonhwe (kunyanya kuchengetedza).ina
Kusagadzikana uku hakungovhiringidzi mabasa ezuva nezuva omurwere uye mararamiro ehupenyu, asiwo kunotadzisa murwere kuramba achishandisa madonhwe emaziso nokuti murwere haadi kuwedzera mamwe madonhwe emaziso kune ziso rakatoshatirwa.5
Kana murwere ane chirwere ichi, corneal staining inowanzoratidza kukanganisa kwekuvimbika kwe corneal epithelium, zvichiratidza kuti kurapwa kunofanira kugadziriswa kubatsira ziso kupora uye kudzivirira kumwe kukanganisa.
Kudzivisa kusangana nemakemikari ane hasha, akadai semeso-akakuvadzwa allergy, zvakanyanya kukosha pakuderedza zvinodhaka-induced conjunctivitis.
Kugara kuchidiwa dosing kunowanzodiwa nekuti madonhwe emeso ane yakaderera bioavailability-chete 5-10% yemushonga inowanikwa pamusoro peziso6-uye inokurumidza kushambidzwa nekubwaira uye nelacrimation.
Mishonga-yakavharidzirwa yekuonana lenses inopa akati wandei mabhenefiti anogona kubvisa mamwe ematambudziko ane chekuita nemadonhwe emeso, anosanganisira:
Mushonga unowedzerwa kune lens panguva yekugadzira, iyo inosanganisirawo autoclave sterilization nhanho.Nokudaro, hazvidi zvinodzivirira zvakadai seBAC, izvo zvinoputsa zvisungo pakati pe corneal epithelial cells.Lenzi imwe neimwe inopa hutachiona hwemushonga.
Medication-coated contact lenzis anoendesa mushonga mukati memaawa, saka anogara pamusoro peziso kwenguva yakareba kupfuura madonhwe emeso anosuka nekukurumidza.Iyo diffusion-yakavakirwa kuburitsa mbiri yeanosangana lenzi inovatendera kuti vaunze madhasi anowirirana kwete madosi anowanzoitika anodiwa kune mamwe madonhwe eziso.
Nekubatanidza kurapwa nekugadzirisa kwekuona mune yakasununguka etafilcon A disposable contact lenses, varwere havadi kufunga nezvechirongwa chemishonga.Iyi ibhenefiti inonyanya kuvimbisa kune varwere vanoomerwa nekugara pahurongwa.
Mishonga-yakavharidzirwa yekuonana lenses inogona kugadzirisa mamwe ematambudziko ane chekuita nemadonhwe emeso, asi mubvunzo unotevera une musoro wevashandi vekuchengetedza maziso ndewekuti, "Ndeipi mhedzisiro yekupfeka zuva nezuva lenses pamusoro peziso?"

Anonyanya Kuzivikanwa Malenzi
Ini nevandinoshanda navo takaongorora dhata kubva mumiyedzo miviri yakafanana yekuchengetedza kiriniki iyo yakatora mavhiki gumi nemaviri uye yakabatanidza vanokwana mazana mashanu nemakumi matanhatu vanopfeka lens.Varwere 374 vakapfeka lenzi dzebvunzo uye varwere 186 vakapfeka lenzi dze placebo.
Cornea tsvina ine fluorescein yakaitwa pakutanga uyezve mushure me1, 4, 8, uye mavhiki gumi nemaviri ekupfeka lens.Pakanga pasina mutsauko wakakosha mukusvibisa pakati peboka rezvinodhaka rakavharwa lens uye boka re placebo pakushanya kwese (95.86% uye 95.88% giredhi 0, zvichiteerana, pamavhiki gumi nemaviri).Mavara ese aive akareruka kana kuronda.
Mushure memavhiki e4 ekupfeka, mapoka ose ari maviri akawana kuderedzwa kwemaitiro ekusvibiswa kwekorneal kubva pakutanga.Kuchinja kunoonekwa uku kunogona kunge kuri nekuda kwevarwere vanochinja kubva kuma lens avo enguva dzose kuenda kune chinhu chitsva (etafilcon A, ine yakakwira mvura ye7) uye / kana yekupfeka regimen (kamwe pazuva, iyo inotora equation kunze kweiyo equation) kuchenesa. mhinduro lenzi).Kuomerera kumalenzi ekudzidza kwaive kwakafanana mumapoka maviri (inenge 92%).
Mukupedzisa, mune yakakura, yakanyatsodzorwa, yakapetwa kaviri-mapofu yekiriniki yekudzidza, tinogona kugumisa nechivimbo kuti iyi antihistamine-releasing contact lens haina kunyanya kukanganisa kuvimbika kwekorneal epithelium.
Maziso akapfeka aya madhiragi-akavharidzirwa ekubatanidza lenses haafaniri kutaridzika chero akasiyana nemeso akapfeka asina-medicated contact lenses, icho chinhu chakakosha chekubatanidzwa kusina musono mukuita kwemaitiro aya.
Iko hakuna mutsauko mukuita kwekukodzera lenzi kana kuongorora chiratidzo.Varwere vanongoda kuziva zvakawanda pamusoro pemalenzi kuitira kuti vawane chiono chavanoda uye vawane rubatsiro rwakawanda nealeji yemaziso.
Uchapupu hwekuti kuwedzerwa kwe antihistamines hakuwedzere corneal epithelial kukuvara kana ichienzaniswa neyakajairwa contact lenses inokurudzira sezvo isu tichitarisira kuwedzera kushandiswa kwemishonga-yakavharwa maitiro.